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Targeting the BCKDK/BCLAF1/MYC/HK2 axis to alter aerobic glycolysis and overcome Trametinib resistance in lung cancer

Hao Wu, Jiajia Yang, Zixia Yang, Yan Xiao, Ran Liu, Jing Jia, Xinrui Zhang, Yuting Zhang, Zheng Fu, Zhi Yao, Junqiang Lv

2025Cell Death and Differentiation11 citationsDOI

Topics & Concepts

TrametinibGlycolysisAnaerobic glycolysisCancer researchCancerMedicineLung cancerOncologyBiologyInternal medicineGeneticsMetabolismSignal transductionMAPK/ERK pathwayCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationRNA modifications and cancer
Targeting the BCKDK/BCLAF1/MYC/HK2 axis to alter aerobic glycolysis and overcome Trametinib resistance in lung cancer | Litcius