Gastrodin extends the lifespan and protects against neurodegeneration in the <i>Drosophila</i> PINK1 model of Parkinson's disease
Jianzheng He, Li Xu, Xu Li, Shipei Yang, Yaling Li, Xingyao Lin, Minghui Xiu, Xuexiang Li, Xuexiang Li, Yongqi Liu
Abstract
Gastrodin feeding extends lifespan, improves antioxidant ability, and delays the onset of a Parkinson-like phenotypes in Pink1 B9 mutant, but does not ameliorate the tau-induced neurobehavioral deficits in Drosophila melanogaster.
Topics & Concepts
GastrodinNeuroprotectionPharmacologyNeurodegenerationOxidative stressDopaminergicSuperoxide dismutaseAntioxidantParkinson's diseaseDrosophila melanogasterBiologyMedicineDopamineChemistryBiochemistryNeuroscienceInternal medicineDiseaseChromatographyGeneBiological and pharmacological studies of plantsCholinesterase and Neurodegenerative DiseasesCircadian rhythm and melatonin