Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer
Xiao Han, Shujuan Du, Xiaoting Chen, Xuehua Min, Zhongwei Dong, Yuyan Wang, Caixia Zhu, Fang Wei, Shujun Gao, Qiliang Cai
Abstract
This study uncovers β-catenin-fascin axis as a key signal in response to extracellular lactate and indicates that antagonist of LA may serve as a potential clinical intervention for cancer development.
Topics & Concepts
FascinCell biologyCell migrationCell adhesionCateninCancer researchCancer cellChemistryCellBiologyCancerInternal medicineSignal transductionBiochemistryMedicineActinWnt signaling pathwayRNA Research and SplicingHeat shock proteins researchCaveolin-1 and cellular processes