Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study
Takdir Tahir, Nur Febrianti, Sri Wahyuni, Rabia Rabia, Yuliana Syam
Abstract
To evaluate the acute wound healing potential of RDFE cream on type III collagen and EGF levels. Male Albino Wistar rats have randomly divided into three groups: negative control received base cream, positive control administered with 10% zalf povidone and RDFE group was treated with RDFE cream. The healing effects were assessed on EGF, type III collagen, wound diameter, tissue granulation, and epithelization, for 3, 7, 11, and 14 days post-treatment. On the 3rd-day post-treatment, the greatest reduction in wound diameters were shown significantly in the positive control among groups (p < 0.05). Although the data were statistically insignificant, RDFE groups showed the highest level of type III collagen among groups after 7-day treatment (p > 0.05). The effect of RDFE cream in the wound healing process on type III collagen appeared on day 7. However, an increase of EGF levels was not observed following RDFE treatment.