Causal effects of inflammatory protein biomarkers on inflammatory diseases
Weronica E. Ek, Torgny Karlsson, Julia Höglund, Mathias Rask‐Andersen, Åsa Johansson
Abstract
). IL-12B protects against psoriasis and psoriatic arthropathy, LAP-TGF-β-1 protects against osteoarthritis, TWEAK protects against asthma, VEGF-A protects against ulcerative colitis, and LT-α protects against both type 1 diabetes and rheumatoid arthritis. In contrast, IL-18R1 increases the risk of developing allergy, hay fever, and eczema. Most proteins showed protective effects against development of disease rather than increasing disease risk, which indicates that many disease-related biomarkers are expressed to protect from tissue damage. These proteins represent potential intervention points for disease prevention and treatment.
Topics & Concepts
InflammationInflammatory responseMedicineComputational biologyImmunologyBioinformaticsBiologyGenetic Associations and EpidemiologyDiabetes and associated disordersAdipokines, Inflammation, and Metabolic Diseases