Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics
Wanrou Jiang, Yongjun Wu, Xiuyun He, Ling Jiang, Wanyi Zhang, Wenjuan Zheng, Min Hu, Chaofu Zhu
Abstract
Chemotherapy-induced diarrhea (CID) is a common and harmful side effect of chemotherapy, greatly impacting patients' quality of life and potentially compromising their chances of survival. Disruption of the balance in intestinal microbiota and compromised integrity of the intestinal barrier are key factors contributing to CID caused by mucositis. This paper investigated the mechanism through which intestinal microbiota activate Toll-like receptors and STING pathways to mediate intestinal mucosal inflammation resulting from immune responses in the gut, uncovering a novel mechanism of intestinal microbiota in chemotherapy-induced diarrhea, and suggesting innovative approaches for the prevention and management of CID.