Comprehensive Analysis of mRNA Expression Profiling and Identification of Potential Diagnostic Biomarkers in Coronary Artery Disease
Jiaxin Chen, Shu He, Yanjun Wang, Xiongkang Gan, Yaqing Zhou, Lei Hua, Can Hou, Sheng Zhang, Hanxiao Zhou, En‐Zhi Jia
Abstract
< 0.001), respectively. We described the characteristics of mRNA expression in the peripheral blood of CAD patients and controls by RNA-seq. Combined with Spearman correlation analysis and ROC analyses, BTRC and UBE2D2 genes had significantly diagnostic values, which may have potential to act as novel diagnostic biomarkers and therapeutic targets for CAD.
Topics & Concepts
Coronary artery diseaseReceiver operating characteristicTranscriptomeBiologyGene expressionGene expression profilingGeneConfoundingFold changeInternal medicineMolecular biologyMedicineGeneticsRNA modifications and cancerCircular RNAs in diseasesGalectins and Cancer Biology