A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking
Heba A.H. Elshemy, Mohamed A. Zaki, Enas Mohamed, Shabana I. Khan, Phoebe F. Lamie
Topics & Concepts
Plasmodium falciparumChemistryIndole testDihydrofolate reductaseDocking (animal)StereochemistryIC50Combinatorial chemistryActive siteEnzymeAntimalarial AgentMutantSelectivityIn vitroBiochemistryMalariaGeneCatalysisBiologyImmunologyNursingMedicineComputational Drug Discovery MethodsHIV/AIDS drug development and treatmentMulticomponent Synthesis of Heterocycles