<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia
Grzegorz Sienski, Priyanka Narayan, Julia Maeve Bonner, Nora Kory, Sebastian Boland, Aleksandra Arczewska, William T. Ralvenius, Leyla Anne Akay, Elana R. Lockshin, Liang He, Blerta Milo, Agnese Graziosi, Valeriya Baru, Caroline A. Lewis, Manolis Kellis, David M. Sabatini, Li‐Huei Tsai, Susan Lindquist
Abstract
APOE4 -disrupted intracellular lipid homeostasis in human and yeast cells was reversed by promoting phospholipid synthesis through choline supplementation.
Topics & Concepts
HomeostasisIntracellularCell biologyChemistryNeuroscienceBiologyNuclear Receptors and SignalingMitochondrial Function and PathologyPeroxisome Proliferator-Activated Receptors