Synthesis of 2,2’‐Bipyridines through Catalytic C−C Bond Formations from C−H Bonds
Wided Hagui, Kiruthika Periasamy, Jean‐François Soulé
Abstract
Abstract The present review describes the homogenous catalytic methodologies for the synthesis of 2,2’‐bipyridines involving C−C bond formation from C−H bond. There are three main approaches to build well‐decorated 2,2’‐bipyridines from C−H bond cleavage: i) the formation of C2−C2′ bond by the dimerization of (activated) pyridines, ii) the C−H bond heteroarylation of activated pyridine, or iii) the late‐stage functionalization of (activated) 2,2’‐bipyridines including photoredox processes. Besides the scope and limitation of each methodologies, the relevant mechanisms of reaction are also discussed.
Topics & Concepts
ChemistryCatalysisBond cleavagePyridineBondSurface modificationPhotoredox catalysisCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryPhysical chemistryPhotocatalysisEconomicsFinanceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions