Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling
Zhimin Qi, Huihui Ji, Monika Le, Hanmei Li, Angela Wieland, Sonja Bauer, Li Liu, Michaël Wink, Ingrid Herr
Abstract
through insulin/IGF-1 signaling. Our results provide the basis for a nutritional sulforaphane-enriched strategy for the promotion of healthy aging and disease prevention.
Topics & Concepts
LongevitySulforaphaneInsulinCell biologyCaenorhabditis elegansInsulin receptorBiologyInsulin-like growth factorChemistryEndocrinologyBiochemistryGeneticsGrowth factorReceptorGeneInsulin resistanceGenomics, phytochemicals, and oxidative stressGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatonin