The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro
Klaudia Ciesielska-Figlon, Agnieszka Daca, Adam Kokotkiewicz, Maria Łuczkiewicz, Bożena Zabiegała, Jacek M. Witkowski, Katarzyna A. Lisowska
Abstract
T lymphocytes, induced cell death in a dose-dependent manner, and reduced the expression of CD28 and CD25 antigens essential for lymphocyte activation. TQ inhibited the proliferation of T lymphocytes and induced cell death, particularly in high concentrations. Meanwhile, p-cymene did not influence lymphocyte proliferation. However, its high concentration induced cell necrosis. These results show that the essential oil from Nigella sativa has powerful immunomodulatory properties, which, at least partially, are related to the TQ component.
Topics & Concepts
ThymoquinoneApoptosisNigella sativaT cellFlow cytometryCD28Cell growthCD8CD3Molecular biologyEssential oilProgrammed cell deathTrypan blueBiologyChemistryPharmacologyAntigenTraditional medicineBiochemistryImmunologyImmune systemMedicineFood scienceAntioxidantNigella sativa pharmacological applicationsBioactive Compounds and Antitumor Agents