Arginine and Endothelial Function
Jessica Gambardella, Wafiq Khondkar, Marco Bruno Morelli, Xujun Wang, Gaetano Santulli, Valentina Trimarco
Abstract
Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
Topics & Concepts
ArginineNitric oxideImmune systemDiabetes mellitusMedicineArginaseVascular toneEndotheliumDiseaseInternal medicineBiologyImmunologyAmino acidBiochemistryEndocrinologyNitric Oxide and Endothelin EffectsCardiac Ischemia and ReperfusionHeart Rate Variability and Autonomic Control