Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation
Zhen Wang, Hong Zhou, Huaping Zheng, Xikun Zhou, Guobo Shen, Xiu Teng, Xiao Liu, Jun Zhang, Xiaoqiong Wei, Zhonglan Hu, Fanlian Zeng, Yawen Hu, Jing Hu, Xiaoyan Wang, Shuwen Chen, Juan Cheng, Chen Zhang, Yi-Yue Gui, Song Zou, Yan Hao, Qixiang Zhao, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang, Yuquan Wei, Wei Li, Jiong Li
Abstract
(T cell receptor delta chain) knockout mice, which show deficient receptor expression in all adult lymphoid and epithelial organs; TLR: toll-like receptor; TNF/TNF-α: tumor necrosis factor; WOR: wortmannin; WT: wild-type; γδT17 cells: IL17A-producing γδ T cells.
Topics & Concepts
AutophagyATG5HMGB1InflammationBiologySequestosome 1Cell biologyPsoriasisChemokineImmunologyCancer researchApoptosisBiochemistryAutophagy in Disease and TherapyAdvanced Glycation End Products researchInflammasome and immune disorders