Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols
Xing‐Zhong Shu, Feng‐Feng Pan, Peng Guo, Xiaochuang Huang
Abstract
Abstract Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.
Topics & Concepts
ChemistryCatalysisHalideNickelPrimary (astronomy)OxalateOrganic chemistryCombinatorial chemistryPhysicsAstronomyAsymmetric Hydrogenation and CatalysisChemical Synthesis and ReactionsOxidative Organic Chemistry Reactions