Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase
Hamza Mechchate, Abdualrahman Mohammed Abdualkader, James Bradshaw Bernacchi, Keshav Gopal, Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Amanda A. Greenwell, Xingxing Kong, Peter A. Crawford, Rami Al Batran
Abstract
Most studies investigated ketone body metabolism under pathological conditions, whereas the role of ketone body metabolism in regulating normal physiology has been relatively understudied. To address this gap, we used lean mice lacking muscle ketone body oxidation enzyme SCOT. Our work demonstrates that deleting muscle SCOT has no impact on glucose and fat metabolism in lean mice, but it disrupts muscle BCAA catabolism and causes an accumulation of BCAAs by altering BCATm.
Topics & Concepts
CatabolismKetone bodiesMetabolismEndocrinologyInternal medicineEnzymeKetoneEnergy metabolismBeta oxidationBiologyChemistryBiochemistryMedicineOrganic chemistryDiet and metabolism studiesAdipose Tissue and MetabolismMetabolism and Genetic Disorders