MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
Tong Dai, Lei Zhang, Yu Ran, Meirong Zhang, Bing Yang, Huasong Lu, Shixian Lin, Long Zhang, Fangfang Zhou
Topics & Concepts
IRF3SUMO proteinSignal transducing adaptor proteinCell biologyUbiquitinPhosphorylationBiologyChemistryBiochemistryReceptorInnate immune systemGeneinterferon and immune responsesUbiquitin and proteasome pathwaysRNA Research and Splicing