Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes
Jian Li, Shangrong Zhu, Yue Xu, Xue-Chen Lu, Zheng-Bing Wang, Li Liu, Defeng Xu
Abstract
a rhodium-catalyzed annulation of triazoles and aldehydes is achieved. Various oxazole derivatives could be obtained in good to excellent yields. A concise synthesis of antimycobaterial natural products balsoxin and texamine has been achieved using this method.
Topics & Concepts
AnnulationRhodiumCatalysisChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCyclopropane Reaction MechanismsClick Chemistry and ApplicationsCatalytic C–H Functionalization Methods