Litcius/Paper detail

Identification of N-(3-(methyl(3-(orotic amido)propyl)amino)propyl) oleanolamide as a novel topoisomerase I catalytic inhibitor by rational design, molecular dynamics simulation, and biological evaluation

Huang Zeng, Huasong Xie, Qiaonan Ma, Yuanbei Zhuang, Baoping Luo, Mei Liao, Hua Nie, Junwei He, Zhanyong Tang, Shengyuan Zhang

2023Bioorganic Chemistry7 citationsDOI

Topics & Concepts

ChemistryRational designTopoisomeraseMolecular dynamicsCatalysisAmino acid residueBiochemistryStereochemistryDocking (animal)DNAComputational chemistryPeptide sequenceGeneNanotechnologyMedicineNursingMaterials scienceCancer therapeutics and mechanismsLung Cancer Research StudiesAntibiotics Pharmacokinetics and Efficacy
Identification of N-(3-(methyl(3-(orotic amido)propyl)amino)propyl) oleanolamide as a novel topoisomerase I catalytic inhibitor by rational design, molecular dynamics simulation, and biological evaluation | Litcius