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Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress

Thiago Ângelo Smaniotto, Angela Maria Casaril, Darling de Andrade Lourenço, Fernanda Severo Sabedra Sousa, Fabiana K. Seixas, Tiago Collares, Rafael Woloski, Luciano da Silva Pinto, Diego Alves, Lucielli Savegnago

2023Psychopharmacology17 citationsDOI

Topics & Concepts

NeuroinflammationOxidative stressNasal administrationEndocrinologyBehavioural despair testTail suspension testInternal medicineNeurotrophic factorsHippocampusMedicineCorticosteroneChronic stressAntidepressantPsychologyPharmacologyInflammationHormoneReceptorStress Responses and CortisolTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms
Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress | Litcius