Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans
Quanzhen Lv, Lan Yan, Jinxin Wang, Jia Feng, Lu Gao, Lijuan Qiu, Wen Chao, Yulin Qin, Yuanying Jiang
Abstract
The development of new antifungal drugs is critical for solving the problem of antifungal resistance and expanding the limited variety of clinical antifungal drugs. Based on the modification of the pyrylium salt SM21, a new lead compound, xy12, was synthesized which was effective against Candida species both in vitro and in vivo .
Topics & Concepts
Candida albicansOxidative phosphorylationBiologyTranscriptomeCorpus albicansMitochondrionMutantBiochemistryMicrobiologyGene expressionGeneAntifungal resistance and susceptibilityFungal Infections and StudiesOral microbiology and periodontitis research