High-sensitivity biomedical sensor based on photoacoustic and cavity enhanced absorption spectroscopy with a new software platform for breath analysis
İsmail Bayraklı, Hatice Akman, Filiz Sarı
Abstract
An easy-to-use highly sensitive sensor is reported for trace gas analysis. A near-infrared fiber-coupled external cavity diode laser in combination with a photoacoustic spectroscopy cell and a cavity enhanced absorption spectroscopy cell is used for analysis of trace gases. A software platform for direct absorption and wavelength modulation spectroscopy is developed in order to identify and quantify the molecules and to achieve a higher signal-to-noise ratio. Considering all of these features, the main advantage of our system is to analyze two different samples simultaneously and quickly. Trace gas measurement is assessed, and a detection limit of 1.5 ppb at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>6528.76</mml:mn> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">c</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">m</mml:mi> </mml:mrow> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> for ammonia is demonstrated. Furthermore, the sensor with our software platform can be easily used outside of the laboratory, for example, in hospitals.