Mechanosensor YAP cooperates with TGF-β1 signaling to promote myofibroblast activation and matrix stiffening in a 3D model of human cardiac fibrosis
Sara Ragazzini, Franca Scocozza, Giacomo Bernava, Ferdinando Auricchio, Gualtiero I. Colombo, Marianna Barbuto, Michele Conti, Maurizio Pesce, Gloria Garoffolo
Topics & Concepts
Cardiac fibrosisExtracellular matrixMyofibroblastFibrosisCell biologyTransforming growth factorParacrine signallingSignal transductionCancer researchVentricular remodelingMyocardial fibrosisMedicineHeart failurePathologyBiologyInternal medicineReceptorCellular Mechanics and InteractionsTissue Engineering and Regenerative MedicineCardiac Fibrosis and Remodeling