Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis
Sumit, Devesh Chandra, Upendra Sharma
Abstract
In the last two decades tremendous progress has been made in transition-metal (TM)-catalyzed C-H bond functionalization, paving the way to design complex molecules. Despite significant advances, enantioselective C-H activation is still in the age of infancy. For the enantioselective synthesis, several TM catalyst based approaches are well known, including kinetic resolution (KR) and its advanced versions [dynamic kinetic resolution (DKR) and parallel kinetic resolution (PKR)]. These strategies have recently been successfully applied synergetically with the TM catalyzed C-H activation to achieve enantioselective synthesis in a more economical and sustainable way. This review will summarize the recent advancements made towards merging KR with TM-catalysed C-H activation for enantioselective synthesis.