Tumor-neuroglia interaction promotes pancreatic cancer metastasis
Dan Su, Xiaofeng Guo, Leyi Huang, Huilin Ye, Zhiguo Li, Longfa Lin, Rufu Chen, Quanbo Zhou
Abstract
: Schwann cells were extensively distributed in the PDAC tumor microenvironment and high level of intra-tumoral SC markers could serve as an independent prognostic factor for poor survival of patients with PDAC. The tumor-neuroglia interaction is indispensable for SCs to acquire a tumor-facilitating phenotype. Targeting the tumor-neuroglia interplay might be a promising strategy to treat PDAC.
Topics & Concepts
Pancreatic cancerMetastasisCancerCancer metastasisCancer cellMedicineCancer researchPathologyNeuroscienceBiologyInternal medicineCancer, Stress, Anesthesia, and Immune ResponseCancer Cells and MetastasisGlioma Diagnosis and Treatment