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Structural basis of CD4 downregulation by HIV-1 Nef

Yonghwa Kwon, Robyn M. Kaake, Ignacia Echeverria, Marissa Suarez, Mohammad Karimian Shamsabadi, Charlotte A. Stoneham, Peter W. Ramirez, Jacob Kress, Rajendra Singh, Andrej Šali, Nevan J. Krogan, John Guatelli, Xiaofei Jia

2020Nature Structural & Molecular Biology66 citationsDOIOpen Access PDF

Topics & Concepts

Downregulation and upregulationEndocytosisCell biologySignal transducing adaptor proteinCytoplasmImmune systemPlasma protein bindingViral proteinClathrinChemistryBiologyReceptorVirusVirologySignal transductionBiochemistryImmunologyGeneHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology
Structural basis of CD4 downregulation by HIV-1 Nef | Litcius