Continued Low Efficacy of Artemether-Lumefantrine in Angola in 2019
Pedro Rafael Dimbu, Roberta Horth, Ana Luísa Micolo Cândido, Carolina Miguel Ferreira, Felismina Caquece, Luzala Garcia, Kialanda André, García Nazaré Pembele, Domingos Jandondo, Belmira José Bondo, Benjamin Nieto Andrade, Sarah M. Labuda, Gabriel Ponce de León, Julia Kelley, Dhruviben Patel, Samaly S. Svigel, Eldin Talundzic, Naomi W. Lucchi, Joana Morais, Filomeno Fortes, José Franco Martins, Mateusz M. Pluciński
Abstract
Biennial therapeutic efficacy monitoring is a crucial activity for ensuring the efficacy of currently used artemisinin-based combination therapy in Angola. Children with acute uncomplicated Plasmodium falciparum infection in sentinel sites in the Benguela, Zaire, and Lunda Sul Provinces were treated with artemether-lumefantrine (AL) or artesunate-amodiaquine (ASAQ) and monitored for 28 days to assess clinical and parasitological responses. Molecular correction was performed using seven microsatellite markers.