Surface modification of the Ti surface with nanoscale bio-MOF-1 for improving biocompatibility and osteointegration <i>in vitro</i> and <i>in vivo</i>
Jiaxin Wu, Shaokang Jiang, Wenjia Xie, Yiyuan Xue, Mingxin Qiao, Xiangjun Yang, Xin Zhang, Qianbing Wan, Jian Wang, Junyu Chen, Xibo Pei
Abstract
release, which up-regulated the expression of osteogenesis-related genes and proteins. Furthermore, bio-MOF-1 coating of Ti implants enhanced early osseointegration at the bone-implant interface. This study demonstrates the promising potential of bio-MOF-1 coatings with the osteogenic effect for surface modification in bone tissue engineering.
Topics & Concepts
BiocompatibilityOsseointegrationMaterials scienceSurface modificationNanoscopic scaleIn vivoNanotechnologySurface (topology)Biomedical engineeringChemical engineeringImplantMedicineMetallurgyEngineeringSurgeryGeometryBiotechnologyBiologyMathematicsBone Tissue Engineering MaterialsMetal and Thin Film MechanicsMXene and MAX Phase Materials