IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells
Jie Cheng, Timothy G. Myers, Callie Levinger, Princy Kumar, Jai Kumar, Bruktawit Goshu, Alberto Bosque, Marta Catálfamo
Abstract
-specific T cells. This new immunomodulatory effect of IL-27 on HIV-specific T cell function suggests its potential therapeutic use in cure strategies.
Topics & Concepts
TIGITSTAT1T cellCell biologyCytotoxic T cellCD8BiologyIL-2 receptorSignal transductionChemistryImmunologyImmune systemIn vitroGeneticsImmune Cell Function and InteractionHIV Research and TreatmentT-cell and B-cell Immunology