Directed evolution of adenine base editors with increased activity and therapeutic application
Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees, Noris M. Solá-Esteves, Luis Barrera, David A. Born, Aaron Edwards, Jason M. Gehrke, Seung‐Joo Lee, Alexander Liquori, Ryan Murray, Michael S. Packer, Conrad Rinaldi, Ian M. Slaymaker, Jonathan Yen, Lauren Young, Giuseppe Ciaramella
Topics & Concepts
DeaminationAdenosine deaminasePoint mutationRNA editingBiologyDNAGenome editingNobel laureateComputational biologyRNACRISPRMolecular biologyGeneGeneticsAdenosineBiochemistryEnzymeMutationPoetryLiteratureArtCRISPR and Genetic EngineeringRNA regulation and diseaseRNA Interference and Gene Delivery