Mitochondrial supercomplex assembly regulates metabolic features and glutamine dependency in mammalian cells
Kun Zhang, Linjie Chen, Bo Wang, Deyu Chen, Xianglai Ye, Xinyu Han, Quan Fang, Can Yu, Jia Wu, Sihan Guo, Lifang Chen, Yu Shi, Lan Wang, Cheng Huang, Hao Li, Lu Shen, Qiongya Zhao, Liqin Jin, Jianxin Lyu, Hezhi Fang
Abstract
Our results reveal the regulatory role of mitochondrial supercomplexes in glutaminolysis which may fine-tune the fate of cells with different nutrient availability.
Topics & Concepts
GlutamineMitochondrionCitric acid cycleOxidative phosphorylationCell biologyGlutaminolysisBiochemistryBiologyInner mitochondrial membraneRespiratory chainFlux (metallurgy)ChemistryMetabolismAmino acidOrganic chemistryMitochondrial Function and PathologyATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism