Population Pharmacokinetics and Pharmacodynamics of Meropenem in Critically Ill Pediatric Patients
Jumpei Saito, Kensuke Shoji, Yusuke Oho, Hiroki Kato, Shotaro Matsumoto, Satoshi Aoki, Hidefumi Nakamura, Takanori Ogawa, Mayumi Hasegawa, Akimasa Yamatani, Isao Miyairi
Abstract
increased by 66% in patients on CRRT in the final model. Dosing simulations suggested that the standard dosing regimen provided insufficient PD exposures of a 100% free time above the MIC, and higher doses (40 to 80 mg/kg of body weight/dose every 8 h) with a prolonged 3-h infusion were required to ensure the appropriate PD exposures for patients with SIRS. Our PK model indicated that critically ill pediatric patients are at risk of subtherapeutic exposure under the standard dosing regimen of MEM. A larger, prospective investigation confirming the safety and efficacy of higher concentrations and prolonged infusion of MEM is necessary.