Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages
Xueqin Li, Xin Chen, Shengzhe Gong, Jie Zhao, Yao Chen, Hanyong Zhu, Rui Xiao, Yongqin Qin, Rongqing Li, Na Sun, Xiangyang Li, Fuxing Dong, Tingting Zhao, Yuchen Pan, Jing Yang
Abstract
An increase in intratumoral platelets promoted CRC growth and metastasis by CD62P binding to PSGL-1 expressed on TAMs, leading to JNK/STAT1 signaling activation, which promoted C5 transcription and activated the C5a/C5aR1 axis in TAMs. Our study examined the mechanism of the crosstalk between platelets and TAMs to exacerbate CRC development and proposed a potential therapeutic strategy for CRC patients.
Topics & Concepts
PlateletChemistrySTAT1STAT proteinPlatelet activationCancer researchCell biologyMolecular biologySignal transductionBiologyImmunologySTAT3Inflammatory Biomarkers in Disease PrognosisImmune cells in cancerImmune Cell Function and Interaction