High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance
David B. Lombard, William Köhler, Angela H. Guo, Christi M. Gendron, Melissa Han, Weiqiao Ding, Yang Lyu, Tsui‐Ting Ching, Feng‐Yung Wang, Tuhin S. Chakraborty, Zaneta Nikolovska‐Coleska, Yuzhu Duan, Thomas Girke, Ao‐Lin Hsu, Scott D. Pletcher, Richard A. Miller
Abstract
, although not in testing performed in worms and flies with a more restricted set of compounds. Transcriptomic analysis and genetic studies implicated Nrf2/SKN-1 signaling in stress resistance provided by two protective compounds, cardamonin and AEG 3482. Small molecules identified in this work may represent attractive tools to elucidate mechanisms of stress resistance in mammalian cells.
Topics & Concepts
LongevityParaquatBiologyCaenorhabditis elegansTranscriptomeOxidative stressDNA damageCell biologyGeneticsComputational biologyGeneBiochemistryDNAGene expressionGenetics, Aging, and Longevity in Model OrganismsGenomics, phytochemicals, and oxidative stressPlant Stress Responses and Tolerance