Cinnamon: an aromatic condiment applicable to chronic kidney disease
Laís de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly Cristhiny Mendes de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, L. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Abstract
Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has shown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention for chronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamic acid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are common complications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complications observed in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.