Cushing’s disease and bone
Aleksandra Zdrojowy-Wełna, Barbara Stachowska, Marek Bolanowski
Abstract
Bone impairment associated with Cushing's disease (CD) is a complex disorder, mainly involving deterioration of bone quality and resulting in an increased fracture rate, often despite normal bone mineral density. Bone complications are common in patients with CD at the time of diagnosis but may persist even after successful treatment. There is currently no agreement on the optimal diagnostic methods, thresholds for anti-osteoporotic therapy and its timing in CD. In this review, we summarize the current data on the pathophysiology, diagnostic approach and management of bone complications in CD.
Topics & Concepts
MedicineCushing's diseaseDiseasePathophysiologyBone diseaseBone mineralOsteoporosisHuman physiologyIntensive care medicineInternal medicinePituitary Gland Disorders and TreatmentsBone health and osteoporosis researchGrowth Hormone and Insulin-like Growth Factors