Knockdown and mutation of Pou4f3 gene mutation promotes pyroptosis of cochleae in cisplatin-induced deafness mice by NLRP3/caspase-3/GSDME pathway
Rong Yu, Kai Wang, Wugen Luo, Hongqun Jiang
Topics & Concepts
Gene knockdownPyroptosisCisplatinApoptosisMutantHair cellOtotoxicityTransfectionCell biologyBiologyChemistryMolecular biologyProgrammed cell deathCochleaGeneGeneticsAnatomyChemotherapyInflammasome and immune disordersHearing, Cochlea, Tinnitus, GeneticsCell death mechanisms and regulation