LncRNA Gas5 Regulates Fn1 Deposition Via Creb5 in Renal Fibrosis
Huanhou Su, Jingzhou Xie, Lijing Wen, Shunyi Wang, Sishuo Chen, Jiangchao Li, Cuiling Qi, Qianqian Zhang, Xiaodong He, Lingyun Zheng, Lijing Wang
Abstract
Aim: Although studies on lncRNAs in renal fibrosis have focused on target genes and functions of lncRNAs, a comprehensive interaction analysis of lncRNAs is lacking. Materials & methods: Differentially expressed genes in renal fibrosis were screened, and the interaction between lncRNAs and miRNAs was searched. Results: We constructed a ceRNA network associated with renal fibrosis, by which we found the transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition. Conclusion: Our study not only provides a theoretical basis for the ceRNA regulation mechanism of Gas5 but also provides experimental evidence supporting the use of Gas5 targeting in the treatment of renal fibrosis.