Cobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines
Shuai Jiang, Wenbin Cao, Xiaoping Xu, Shun‐Jun Ji
Abstract
A Co-catalyzed cyclization reaction of isocyanides, azides, and amines to access quinazoline derivatives was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction involved three or four C–N bonds and the formation of one or two rings. The quinazolin-4(H)-imines obtained are proven to be versatile intermediates for further valuable transformations. It was also found that the cobalt catalyst could be isolated from the reaction mixture and reused.
Topics & Concepts
ChemistryCatalysisIsocyanideCobaltCombinatorial chemistryCascade reactionCascadeAtom economySubstrate (aquarium)Reaction conditionsOrganic chemistryGeologyChromatographyOceanographyQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsSynthesis and Biological Evaluation