A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca<sup>2+</sup> release capacity in the skeletal muscle of aged mice
Hiroaki Eshima, Yoshifumi Tamura, Saori Kakehi, Ryo Kakigi, Ryota Hashimoto, Katsuhiko Funai, Ryuzo Kawamori, Hirotaka Watada
Abstract
The aim of this study was to examine the effect of high-fat diet (HFD)-induced obesity on contractile function and Ca 2+ release capacity in aged skeletal muscle. Not only were the force production and peak Ca 2+ levels decreased by aging and HFD feeding, respectively, but also, these interventions had an additive effect in aged HFD-fed mice. These data suggest that the impairment in the contractile force in aged muscle is aggravated by a HFD, which may be due to synergistic dysfunction in intracellular Ca 2+ release.
Topics & Concepts
Internal medicineEndocrinologySkeletal muscleIntracellularChemistryBiologyMedicineBiochemistryAdipose Tissue and MetabolismMuscle metabolism and nutritionExercise and Physiological Responses