A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids
Ahtasham Raza, Stuart A. Archer, Simon D. Fairbanks, Kirsty L. Smitten, Stanley W. Botchway, Jim A. Thomas, Sheila MacNeil, John W. Haycock
Abstract
, acute and rapid photoinduced cell death was observed throughout their depth, including the hypoxic region.
Topics & Concepts
PhototoxicityChemistryPhotochemistrySpheroidAbsorption (acoustics)Singlet oxygenExcited stateRutheniumFluorescencePhosphorescenceBiophysicsOxygenOpticsAtomic physicsPhysicsBiologyOrganic chemistryCatalysisBiochemistryIn vitroNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry