Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
Topics & Concepts
Apolipoprotein EEndocrinologyHuman brainInternal medicineGene isoformAlzheimer's diseaseBiologyAmyloid precursor proteinAmyloid (mycology)Genetically modified mouseGene knockinDiseaseGeneMedicineTransgeneNeurosciencePathologyGeneticsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms