Gut Microbial Dysbiosis Associated with Type 2 Diabetes Aggravates Acute Ischemic Stroke
Xiaojiao Chen, Qiheng Wu, Xuxuan Gao, Huidi Wang, Jiajia Zhu, Genghong Xia, Yan He, Wei Song, Kaiyu Xu
Abstract
We demonstrated an additive effect of type 2 diabetes (T2D) and acute ischemic stroke (AIS) on AIS with T2D (AIS_T2D) patient gut microbiota dysbiosis, and gut dysbiosis associated with T2D was positively correlated with stroke severity in AIS patients. Through animal experiments, we found that cerebral injury was exacerbated by fecal microbiota transplantation from T2D patients compared with that from healthy controls, which was associated with a reduction in short-chain fatty acid (SCFA)-producing bacteria. This study provided a novel view that links T2D and AIS through gut microbial dysbiosis.
Topics & Concepts
Gut floraDysbiosisType 2 diabetesMedicineStroke (engine)Diabetes mellitusInternal medicineImmunologyEndocrinologyMechanical engineeringEngineeringGut microbiota and healthDysphagia Assessment and ManagementDiet and metabolism studies