Significance of Biomarkers in Early Diagnosis of Abdominal Sepsis
Dragana D. Arbutina, Ljiljana Milić, V Cuk, Jovan Juloski, R Radulović, Ana Starčević, Aleksandar Karamarković
Abstract
INTRODUCTION/OBJECTIVE: CRP and PCT are so far among the most valuable preoperative markers for distinguishing sepsis from SIRS. On the first postoperative day the analysis of the relationship between sensitivity and specificity at the different breakpoints used indicates a greater diagnostic accuracy and greater sensitivity of SAA compared to CRP and PCT. In the remaining postoperative period in our study, the ROC curve mostly coincided with the diagonal line, so CRP, PCT, and SAA had little diagnostic accuracy. CONCLUSION: The results of our study suggest that finding a specific marker for the diagnosis of abdominal sepsis, a marker that would differentiate between SIRS and sepsis, pre- and postoperatively, would be very useful.