<i>Helicobacter pylori</i> infection and the prevalence of hypertension in Chinese adults: The Dongfeng‐Tongji cohort
Xuelian Xiong, Jun Chen, Meian He, Tangchun Wu, Handong Yang
Abstract
Abstract Although many studies explored the association between helicobacter pylori ( H pylori ) infection and hypertension, there is no consensus. This study is to investigate the association between H pylori infection and the prevalence of hypertension among a middle‐ and old‐age Chinese population. A cross‐sectional study including 17,100 participants from the Dongfeng‐Tongji cohort study was performed. All participants underwent a 14 C‐urea breath test and a routine health check‐up. Logistics and linear regression with multivariable adjustment were used to quest the association between H pylori infection and hypertension. The individuals with H pylori infection had a higher prevalence of hypertension (57.5% vs 55.1%, P = .002), and infection rate of H pylori in patients with hypertension is higher than that in non‐hypertensive individuals (48.8% vs 46.4%, P = .002). After adjustment for potential confounders, H pylori infection increased the prevalence of hypertension (odds ratio, 1.117, 95% confidence interval (CI), 1.029‐1.213, P = .008). Moreover, compared with participants without H pylori infection, individuals infected had an increase of 0.905 mm Hg (95% CI, 0.025‐1.785, P = .044) for diastolic blood pressure. However, there was no interaction between H pylori infection and traditional risk factors on hypertension. These findings suggested that H pylori infection was positively associated with the prevalence of hypertension.