DBU: A Reaction Product Component
Jacques Мuzart
Abstract
Abstract DBU (1,8‐diazabicyclo[5.4.0]undec‐7‐ene) is traditionally considered to be a non‐nucleophilic base. Nevertheless, DBU possesses nucleophilic properties which mediate organic reactions and may lead to the formation of compounds containing the DBU scaffold. Participation of water to the processes affords there‐component products. The review covers the reactions leading to DBU derivatives showing that the interest of this sterically hindered amidine is not limited to its basic role. Proposed mechanisms are described with, in some cases, personal comments.
Topics & Concepts
ChemistryNucleophileAmidineComponent (thermodynamics)Steric effectsOrganic chemistryNucleophilic additionBase (topology)Product (mathematics)Combinatorial chemistryCatalysisThermodynamicsGeometryMathematical analysisPhysicsMathematicsChemical Synthesis and AnalysisCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis