Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration
Sven Flemming, Anny‐Claude Luissint, Dennis H. M. Kusters, Arturo Raya‐Sandino, Shuling Fan, Dennis W. Zhou, Mizuho Hasegawa, Vicky García‐Hernández, Andrés J. Garcı́a, Charles A. Parkos, Asma Nusrat
Abstract
) exhibited impaired mucosal repair after biopsy-induced colonic wounding and recovery from dextran sulfate sodium-induced colitis. In vitro analyses using human intestinal cell lines after KD of Dsc2 revealed delayed epithelial cell migration and repair after scratch-wound healing assay that was associated with reduced cell-matrix traction forces, decreased levels of integrin β1 and β4, and altered activity of the small GTPase Rap1. Taken together, these results demonstrate that epithelial Dsc2 is a key contributor to intestinal mucosal wound healing in vivo.