Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds
Rakhi Yadav, Dilkhush Meena, Kavita Singh, Rajdeep Tyagi, Yogesh Yadav, Ram Sagar
Abstract
Other than recent synthetic developments, mechanism of resistance of anti-TB drugs is also incorporated in this review. Structure activity relationships of the new benzothiazole derivatives along with the molecular docking studies of selected compounds have been discussed against the target DprE1 in search of a potent inhibitor with enhanced anti-tubercular activity.
Topics & Concepts
BenzothiazoleCombinatorial chemistryChemistryOrganic chemistryTuberculosis Research and EpidemiologySynthesis and biological activityCancer therapeutics and mechanisms