Palladium-Catalyzed Reductive Formylation of Aryl Iodides with CO<sub>2</sub> under Mild Conditions
Dan Li, Wei Li, Wenfang Xiong, Huanfeng Jiang, Chaorong Qi
Abstract
A palladium-catalyzed reductive formylation of aryl iodides with carbon dioxide as the carbonyl source under mild reaction conditions was realized by using a combination of Pd(PCy 3 ) 2 Cl 2 and di-2-pyridyl ketone as the catalyst and phenylsilane as the reductive reagent, leading to a variety of aromatic aldehydes in moderate to excellent yields. The protocol features wide substrate scope, good functional group tolerance, and simple operation.
Topics & Concepts
ChemistryFormylationPalladiumArylCatalysisReagentPhenylsilaneKetoneOrganic chemistryReductive eliminationCombinatorial chemistryMedicinal chemistryAlkylCarbon dioxide utilization in catalysisCO2 Reduction Techniques and CatalystsAsymmetric Hydrogenation and Catalysis