From the Design to the <i>In Vivo</i> Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Sandra Codony, Carla Calvó‐Tusell, Elena Valverde, Sílvia Osuna, Christophe Morisseau, Marı́a Isabel Loza, José Brea, Concepción Pérez, Marı́a Isabel Rodrı́guez-Franco, Javier Pizarro‐Delgado, Rubén Corpas, Christian Griñán‐Ferré, Mercè Pallàs, Coral Sanfeliu, Manuel Vázquez‐Carrera, Bruce D. Hammock, Ferran Feixas, Santiago Vázquez
Abstract
improved the health status of the animals and reduced pancreatic damage, demonstrating that the benzohomoadamantane unit is a promising scaffold for the design of novel sEHIs.
Topics & Concepts
Epoxide hydrolase 2ChemistryIn vivoAdamantaneStereochemistryScaffoldEpoxideRing (chemistry)EnzymePharmacologyMolecular modelCombinatorial chemistryBiochemistryOrganic chemistryMedicineCatalysisBiologyBiomedical engineeringBiotechnologyEicosanoids and Hypertension PharmacologyHormonal Regulation and HypertensionDiet, Metabolism, and Disease